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1. Can MTHFR gene mutation increase the risk of chronic kidney disease?

Yes, MTHFR gene mutation may increase the risk of chronic kidney disease (CKD) in some individuals. MTHFR enzyme plays a critical role in the body’s metabolism of homocysteine, an amino acid that can be toxic at high levels. MTHFR gene mutations can cause a reduction in enzyme activity, leading to elevated homocysteine levels. High homocysteine levels can damage the blood vessels in the kidneys and lead to CKD over time.

Several studies have investigated the relationship between MTHFR gene mutation and CKD, and some have found an increased risk of CKD in individuals with certain MTHFR gene variants. However, other factors such as high blood pressure, diabetes, and obesity are also major risk factors for CKD, and the relationship between MTHFR gene mutation and CKD is not fully understood.

If you have concerns about your kidney health or MTHFR gene mutation, it is recommended that you speak with a healthcare provider who can evaluate your individual needs and make personalized recommendations for management and treatment.