Supplements For Anxiety With MTHFR

We’ve talked about how MTHFR and Anxiety are linked a couple of times and had an interview with anxiety expert Jennifer Bronsnick, but all of that still doesn’t answer one of the biggest questions about anxiety that I get, which is, “What can I take to help me fix it?”

Good question. Obviously, everyone responds differently to different supplements, just like they do with medications, but here are a few of my favorites with some perspective about how they interact with MTHFR. I’m hoping it goes without saying, but balancing your methylation should always be the first step to dealing with anxiety. The rest of these are to clean up anything that is left.

GABA

GABA is, in my opinion, a highly underrated supplement. It is an inhibitory neurotransmitter, meaning it decreases the likelihood that the neuron will fire or send a signal. In the overactive brain of someone with anxiety, this is precisely what we want. It is also crucial to healthy brain functioning, with an estimated 60 – 75% of all neurons being GABAergic (or responsive to GABA.)

There has been a long-standing debate in the research world whether or not GABA that you take by mouth can possibly cross the blood-brain barrier. It is certainly well absorbed and blood levels rise sharply within thirty minutes of taking it, but it is much harder to demonstrate brain levels in a study. Research evidence and theorizing exist on both sides of the fence, but due to its potent clinical effects, I tend to think it either does cross the BBB or it takes action on something else which has a calming effect on the central nervous system and that is just as good.

GABA is probably most known as a sleep aid, helping to calm restless minds into healthy sleep. For anxiety, however, it reduces your feeling of actual anxiety and tension, but also helps to reduce cortisol levels, increase parasympathetic nervous system activity as measured through the vagus nerve (which means your nervous system is trending more toward relaxation than stimulation). The doses used in research tend to be between 30 – 100 mg. There is a great systematic review article about GABA and its effects on anxiety from Frontiers in Neuroscience here.

GABA is the type of supplement that I feel sneaks up on anxiety. What I mean by that is taking a dose regularly that is just below the dose that would make you sleepy (this might take some trial and error) isn’t necessarily going to change your life in that first week, but it does help to get your body into a rhythm of functioning without as much hypervigilance. I love this because it takes the edge off so that you can actually work on mindfulness or breaking mental bad habits in a more protected mental space – like the GABA makes it easier to see the things your mind is doing that it doesn’t need to be doing.

As an aside, GABA also shows remarkable clinical promise for Type I Diabetes, which is insulin-dependent. In much larger doses than those taken for anxiety, GABA helps to boost insulin response in fasting and non-fasting conditions and may help to both protect and restore pancreatic beta cells. While this has very little to do with anxiety in the way we tend to think of it, there is a link between anxiety and blood sugar.

MTHFR and GABA

There is only one relevant study pertaining to MTHFR and GABA levels. This study shows mice with MTHFR polymorphisms to have altered levels of many neurotransmitters, including GABA, in different brain segments relative to wild-type mice. This study showed that mice who were heterozygous for an MTHFR SNP showed altered levels of both GABA, which is inhibitory, and glutamate, which is excitatory, in the amygdala, cerebellum, hypocampus, and thalamus.

Passionflower (Passiflora Incarnata)

Outside of having one of my favorite names in all of herbal medicine, passionflower is remarkable as a calming and soothing agent for anxiety. It can be used for short-term anxiety, such as to help patients remain calm before dental or surgical procedures or long-term for such neuropsychiatric conditions as generalized anxiety disorder and post-traumatic stress disorder. In both cases, passionflower shows remarkable benefits.

A comparison study between liquid passionflower extract and the pharmaceutical drug oxazepam, which is a benzodiazepine, showed equivalent clinical effectiveness over a period of 28 days.

Passionflower has also been used to help people who are addicted to opiates to successfully withdraw. Studies showing passionflower as an addition to clonidine, which is the standard of care, demonstrate better handling of mental symptoms in the clonidine plus passionflower group than the clonidine alone.

Passionflower can be taken as a tea, a liquid extract, or as a capsule or tablet. As with all herbal medicines, quality matters and it’s important to find products that follow the highest standards of manufacture and testing.

While passionflower hasn’t been specifically studied for use in folks with MTHFR mutations, it works well clinically in a wide range of people, and I’ve seen great results in my own clients, the majority of whom have MTHFR polymorphisms. Also, it’s pretty easy to tolerate and side effects are not common.

Adaptogenic Herbs For Anxiety

Adaptogens are herbs that help the human body resist stressors of all kinds. They quite literally help us adapt to all manner of situations with grace and strength, both literal and metaphorical. The most well-known adaptogens are herbs like ginseng, ashwagandha, and licorice which might just as well come with a sub-heading that says “Strong Like Bull.”

While there is, sadly, no research specific to MTHFR and adaptogens, there is a literal boatload of research on adaptogens and anxiety. Ashwagandha, for instance, has been shown to reduce both the feeling of anxiety and also cortisol levels after 60 days in adults with a history of chronic stress.

In general, the effects of adaptogens on cortisol levels and conditions associated with excessive cortisol, including anxiety, fatigue, abdominal obesity, and metabolic syndrome, are extremely well known. These are wonderful therapies for the management of long-term stress and anxiety disorders, although they should be used with practitioner supervision and guidance.

Licorice, for instance, is one of my favorite herbs of all time, but it is known to elevate blood pressures and so is perfect for skinny, high-strung, anxious women like myself, but not a good option for someone who struggles with blood pressure or cardiac issues.

There are, of course, hundreds of other supplements for anxiety but these are three of my go-to staples. Don’t forget to sign up for the mailing list, or join our MTHFR community here.

Share with friends:

S2E20: MTHFR and Anxiety – An Interview with Jennifer Bronsnick

This week on the podcast we’re trying something new. An interview with an anxiety expert who has also gone through her own recovery process with anxiety. The interview was clipped for the podcast episode but you can watch the full thing, on zoom, here.

MTHFR and Anxiety – an Interview with Jennifer Bronsnick.

Jennifer Bronsnick’s suggestions for Anxiety

Jennifer mentions a few tools that have been helpful for her. Here they are!

  • Eliminating alcohol
  • Cutting down or eliminating refined carbs like white flour and sugar
  • HeartMath – for more info about this, click here.
  • Existential Kink – the book by Carolyn Elliott.
  • Getting quiet to actually hear what your body might be trying to say.

Let me know what you think of the interview format – I can do more of this, or not. Just depending on you.

Share with friends:

S2E19: MTHFR and Anxiety

MTHFR and anxiety are intimately linked, mostly, we presume, because your body needs folate to make serotonin, dopamine, epinephrine, and norepinephrine. Those are most of the major neurotransmitters that affect mood and mood disorders including anxiety and depression.

More specifically, a folate molecule is needed to convert BH2 to BH4, and BH4 is needed to convert the amino acid precursor tryptophan into serotonin and tyrosine into dopamine, norepinephrine, or epinephrine. We did a post about it here.

Because of this link, working on optimizing your methylation can have a huge impact on anxiety and depression, but it isn’t the only thing you can do. Of course there are pharmaceuticals for anxiety and I’m not really going to cover those because those will probably be your doctor’s first go-to solution. And that’s fine, but there are other things as well. We’ve already talked about anxiety as a mental bad habit, and also about breaking mental bad habits. So today, let’s talk about steps you can take in your own real life to reduce anxiety.

Eat Regular Meals

This kind of sounds like a soft-ball. Like it couldn’t possibly make a difference to anybody’s anxiety level because it’s just too simple. In reality, keeping your blood sugars balanced and stable can cause a huge drop in anxiety levels, and here is why.

When your blood sugars drop, either from a skipped meal or after a sugar rush and the inevitable sugar crash that follows, your body has a low-sugar stress reaction. Sugar is absolutely vital to the functioning of your brain and so your blood has a tightly regulated amount. If that amount drops, your body literally goes into panic mode, activates your HPA, which is your hypothalamic-pituitary-adrenal axis, and pumps out stress hormones to bring your sugar levels back up.

Skipping meals is incredibly stressful for your body – and that translates to actual stress hormones that affect your level of anxiety. Keeping your blood sugars balanced through the day is far more important than you realize, and if anxiety is an issue for you, then it’s important to back some of the sugar out of your diet and make sure you eat regularly.

I know plenty of people who run on adrenalin and skip meals regularly because they’re too busy, there’s no time when the kids are running around, etc… but making time for this simple self-care can have a huge impact on how stressed you feel and also on the long-term effects of stress like sleep quality, weight gain, belly weight, and fatigue. Interestingly, blood sugar fluctuations and their corresponding changes in insulin levels are also highly linked to brain fog.

Clean Out Your Medicine Cabinet

Oddly a number of medications are known to increase anxiety. Some of those are because they have a negative effect on folate status, like birth control pills or methotrexate. Some are because they cause a caffeine-like reaction (or actually contain caffeine). These include cough and congestion formulas, many pain pills, and cold and flu medications. Also, medications for weight loss are well known for causing anxiety. Also if your dose of thyroid medication is either too low or too high it can lead to anxiety.

Decrease Your Caffeine

First, a disclaimer. I am a *huge* fan of coffee and will never, ever, ask you to stop drinking it. Having said that, different people have different levels of sensitivity to caffeine and also, women at different points in their cycle have different sensitivities to caffeine. It can help to experiment with your caffeine intake to see what works best for you, but keep a symptom tracker for a few months and try different caffeine levels – you might be surprised. In truth, any human with more caffeine than their body can easily process, is going to experience more anxiety, more edginess, and more irritability. That is just biology, so it can be a good idea to check in with your body every now and then and see if the amount you’re getting is ok for you.

Many medications contribute to anxiety, especially those like methotrexate or birth control pills that decrease folate levels.

Exercise, Yoga, and Meditation

These are all well-known moderators of anxiety, so I won’t belabor the point, but there are a few tips.

  • According to a study published in Psychiatry Research, higher intensity exercise like jogging or fast walking shows better results for reducing anxiety than gentle stretching.
  • Yoga shows better effects for anxiety than stretching or resistance training in Parkinson’s disease, but that effect may translate out to the general population as well.
  • Mindfulness meditation (as opposed to other forms) has been well documented to reduce anxiety symptoms.

There are, also, a number of supplements that are helpful for anxiety as well, but we’ll cover that in a separate post.

Thank you so much for listening today and please sign up for the mailing list at tohealthwiththat.com – we’ve got some great things coming this year and I want you to be the first to know.

Share with friends:

S2E17: Happy Holidays and How To Make A New Years Resolution You Will Actually Keep.

First and foremost I want to say happy holidays this week. Spend time with loved ones if you can, and if you aren’t able to be with the people who matter to you, then make sure they know they matter in some way or another. This is the season when we all need to give and receive as much love and care as possible.

The holidays can be a hard time for a lot of people. If you’re struggling this season as so many people are, please reach out to someone. It could be a friend, a practitioner, family, a shelter, or hotline. Ask for help if you need it – you will be surprised at how much help is available.

This year is coming to a close and that brings with it a measure of self reflection and the almost inevitable decision to make some changes. For many of us those changes will come in the form of a New Years Resolution, and this year I’m proposing something a little bit different. Here’s why.

Saying “I love you” to yourself is surprisingly powerful. It only takes a second – try it right now.

2021 has been a tough year. Partly, because it followed 2020, which was also a tough year. Never-ending the global pandemic, many of us have faced some pretty extreme changes to the way we chose to live, the way we socialize, the way we work, the work we do, and our perceived level of freedom. I want to take a minute to acknowledge how much stress we as a collective are actually under and to honor that.

With MTHFR, it is wise to buffer ourselves from stressors like this one, and for many of us, this pandemic has worsened anxiety, increased depression, or deepened or reactivated addictions. Not only that, there is evidence that Covid affects people with MTHFR who have high levels of homocysteine more strongly than it does other folks. I want you to take just a second, take a deep breath, and say something profound. I want you to look in the mirror, right into your own eyes, and say three simple words. “I love you.”

For some of you, that will be kind of awkward or odd, for some it will trigger a smile and for some it will trigger tears. No matter what happens, this is a powerful thing you can do for yourself in only a second and it matters this year.

Now, back to the issue of New Years Resolutions.

I honestly feel that precisely zero people need more stress or striving right now. What we need is more joy, so I’m proposing a different kind of resolution this year – one you might actually keep beyond January 3rd. Here’s how to do it.

  1. Write a list of things that make you happy that you don’t take the time to do right now.  It could be big things (like travel or vacation or family camping trips) or little things (sketching, hiking, or having fresh flowers in the house). Think of at least 20 things.
  2. Take out the ones that are impossible  for some reason (costs too much, borders are closed, have to stay close to home to take care of elderly parents, etc..)  
  3. Make sure there are at least ten good things on your list and if there aren’t, repeat steps one and two until you’ve got ten or more
  4. Make your resolution, just like the big bold one below.

In 2022 I will do one wonderful thing from my happy list every week.

– Love, me.

How’s that for a resolution you can keep?!?

We all need a little more happy and a little more ease right now and putting pressure on yourself, guilting yourself, or being hard on yourself, or setting yourself up for failure isn’t going to help anybody – especially not you.

This year, make a resolution that will make your life better.

Happy New Year, Everybody! Love, Amy.

Share with friends:

What To Expect When You’re Breaking A Mental Bad Habit

Last week we started our conversation about the “bad habit” component, called neuroplasticity, of depression, anxiety, intrusive thoughts, and obsessive or compulsive thoughts. This is, of course, only part of the picture. Neurotransmitter balance is a factor along with the often overlooked physical contributors to depression and other states.


We discussed three main methods for breaking mental bad habits. Those are:

  1. The Fantasy
  2. The Stop and Drop
  3. The Distraction

When you’re first trying this, it can be really helpful to try all three strategies at different times to see what works the best for you. You’ll know it works when you are able to pop yourself out of your mental bad habit – to feel different in your body and to let go of whatever thought pattern it is that you’re working on.

Stages of Resolution With Mental Bad Habits

  1. Learning. In this phase, you’re actually learning to pay attention to your thoughts and that takes more time than you would think. You may find a particular “warning” signal for you – it could be a behavior (like when I’m starting to feel this way I always log on to Facebook and click links that make me angry or I start craving XYZ food. It could also be a physical feeling – a headache in a particular place, a clenching in your belly, pain in your neck or shoulders. It could also be something more subtle like tuning into your mood more frequently.
  2. Out of Control. This phase feels like you’re moving backward. You’ve started tuning in and now you’re actually noticing how much your brain does this thing and it’s a ton! It will seem like your brain is a wild horse racing ahead of you, and it feels like the bad habit is happening more, not less.  That is a GREAT sign because the reality is that you aren’t doing the bad thing more, you’re just noticing more and that is the first step to actually changing it. This can take a few months of diligent attention, but don’t get discouraged – you’re doing it and you’re making progress.
  3. Quietening. In this phase, you start to make tangible progress and you’ll notice that the mental bad habit becomes softer somehow. Quieter.  The thoughts/feelings are still there and they still affect you, but you’re learning to let them go more quickly and it’s easier not to get pulled in by them. 
  4. Maintenance. This phase is amazing.  One day you’ll notice your mental bad habit pop up and the first thought you’ll have is “Oh! I haven’t seen that for a while.” and you’ll dismiss it and move on. This is the phase where you have the freedom to move on to something else because that bad habit is mostly gone.  It’s a good idea to still take proactive action when it pops up, but it is popping up so much less frequently that it becomes almost a curiosity when it’s there.

Great! So I’ll be mentally healthy by next week, right?

Absolutely not. I would love to say it was easy and took no time or effort, but that would be a bald-faced lie. It’s a challenge and it takes time. You’ve probably had this mental bad habit for years if not for your entire adult life, so it will take some time to break it too. And some time doesn’t mean a couple of weeks, it means months and maybe even a year. This isn’t quick, but it is SO. WORTH. IT.

Does This Work Every Time?

This works every time if you stick with it, and when there isn’t some other major imbalance. If your serotonin is actually so low it’s living in the sub basement, then this will still help fix the habit part of it, but it won’t completely normalize the serotonin (but it will bring it up – research shows these techniques are associated with higher levels of both serotonin and melatonin). Although, every day we’re learning more about what this can actually accomplish.

What IS This Witchcraft? It’s Mindfulness.

Yup. That thing that hippies and new-agey types do. Also, everybody who studies neurology and neuroscience of any sort, because as it turns out the effects are so powerful as to be almost unbelievable.

Among the many documented effects of any form of mindfulness are:

  • Increased wellbeing
  • Reduced cognitive reactivity (so external things don’t affect you so much)
  • Reduced inflammation
  • Reduced reactivity of the autonomic nervous system (you don’t get an adrenaline spike every time something bad happens)
  • Higher serotonin
  • Higher melatonin
  • increased telomerase activity (anti-aging)
Share with friends:

Is Your Depression or Anxiety Just a Mental Bad Habit?

Depression and anxiety are common problems for humans. So common that almost all of us will experience one or the other or both in our lifetimes. In truth, both depression and anxiety are normal and healthy reactions to life stressors, grief, and trauma and they have their uses in terms of survival and adaptation. The problem comes, then, when they linger beyond their useful time.

The Neurotransmitter-Only Myth

In modern medicine we tend to compartmentalize and idealize situations in which we can blame a problem on one concrete and measurable thing. Like serotonin. Serotonin is a great thing to blame in medicine. Not only is it concrete and measurable, but we have drugs to change how it is used and processed and therefore, it’s “fixable.” That is all nice and neat and it would be perfect, if this strategy actually worked. Like, really worked.

I am not at all suggesting that this is a bad route of treatment for depression – it’s actually a pretty good one and lots of people see improvement of their symptoms and sometimes even resolution with a drug that affects serotonin, like an SSRI. But, lots of people don’t, which means we have a ways to go.

Last week, we talked about other factors that can lead to depression, and those are generally physical states. These are typically also pretty straightforward to address and will often bump a person from meh, to good. That is tremendous. But what about what is left?

Mental Bad Habits, Also Known As Neuroplasticity

The factor in troubled mental health that I feel is most overlooked is the bad habit factor. Unfortunately, this is a giant factor in our mental health because there is an important survival-related brain function that prioritizes neural pathways that we use frequently, which we call “neuroplasticity.”

Neuroplasticity is part of the way your brain learns what is important to you. The pathways between neurons that you use most frequently get strengthened and prioritized because they matter to you.

Picture it like a path through tall grass. The first time you walk through the tall grass and weeds you have to push through weedy tangles, the plants pull at your legs and they’re so close together that you can feel resistance as you walk. The fifth time you walk the same path, you notice the plants are trampled in that area, there is a natural space opening up and walking is easier. The five hundredth time, there is a dirt trail there where the plants have stopped growing because the path is traveled so frequently. It’s clear and easy and there is no resistance.

Your brain is exactly the same way – the more you use a certain pathway, the easier it becomes to continue to use that pathway. This principle applies to many mental states that could be considered mental bad habits.

  • Anxiety
  • Catastrophizing
  • Depression
  • Negative self-talk
  • Obsessive thoughts
  • Intrusive thoughts
  • Guilty or self-reproaching thoughts.
  • Lack and scarcity

This also applies to many mental states that can be considered mental good habits.

  • Gratitude
  • Mindfulness
  • Acceptance
  • Forgiveness
  • Self acceptance
  • Abundance

Now, does this mean that if you focus on retraining your brain that a lifetime of depression and anxiety can disappear? In all honesty, I think it does, but it also takes a significant amount of work, and sometimes there really are nutritional deficiencies, physical problems, or neurotransmitter imbalances that need to be corrected as well.

Breaking A Mental Bad Habit

There are three techniques that I think are incredibly helpful in breaking a bad habit. The key to all of these is experimenting to see what seems to work best for your particular bad habit, and then repeating the technique over and over again. Mostly, this boils down to practice. So here are the techniques to choose from:

The Fantasy

Say your issue is catastrophizing or anxiety and you get into a place of “what if.” “What if I lose my job and I can’t keep up with the bills and I have to choose between keeping the house or …” We all have these thoughts sometime and they are largely unproductive. This isn’t when most people do effective planning, this is just when they spin out into fear and anxiety. So, here’s what you do.

  1. Notice you’re spinning out. This is actually the hardest part because if you get into this thought frequently, it often runs in the background without you placing any attention on it.
  2. Choose something awesome instead. With the above job-loss fantasy (which is in most cases just a fantasy), replace it with an opposite fantasy. “What if I win the lottery and buy my own jet and …”
  3. Enjoy it for a minute. Really get into the replacement fantasy. Figure out what you would do, imagine how it would feel waking up every day knowing that you can do whatever you want. Think of all the things you could enjoy.
  4. Repeat. Every time you notice anxious thoughts, do this same thing. It takes practice, but you will notice the anxious thoughts coming less frequently, feeling less emotionally compelling, and vanishing more quickly.

The Stop and Drop

This is my personal favorite, just because it’s a nice gap in a crowded mental landscape. Again, the hardest part is noticing your mind.

  1. Notice you’re having a mental bad habit. If you’re doing your mental bad habit – judging yourself, feeling bad about something, obsessing, the first step is always to notice you’re doing it. This means recognizing the thought or feeling in the moment.
  2. Stop. In that moment stop what you’re doing for a few seconds, take a deep breath, and notice your body, your hands, your shoulders, the physical feeling that goes with your mental bad habit. Usually, people notice clenched jaws, fisted hands, bunched-up shoulders, clenched belly, that sort of thing. Let your body relax.
  3. Drop. Take another deep breath and keep your body relaxed and let the thoughts just drop. You don’t really have to do anything with the thought, just let it finish and go away and don’t choose to pick it up right away.
  4. Repeat. Again and again and again. This isn’t quick, but it is so effective. You are literally training your brain and just like training a dog or a horse, it’s all about persistence and repetition.

The Distraction

I learned this technique when my little girl was an early toddler and it applies to adult brains too.

  1. Notice your brain is in a bad place. Again, this first step is the hardest but if you start to pay attention, you will start to catch yourself in places you don’t want to be.
  2. Choose a distraction. Find your own version of a toddler distraction. Something your brain likes to do that isn’t a mental bad habit. It could be a book, a funny youtube video, or a quick game of some kind. Something that is mentally compelling enough to distract you entirely from that thought.
  3. Do your distraction for 1 – 3 minutes. It helps to set a timer so you don’t get lost in your distraction because that isn’t helpful either, but use your distraction as a way to bump your brain out of an unhealthy pattern. I’m not suggesting you binge watch Friends to stop your depression because ultimately, that isn’t the point. Distracting yourself for twelve hours straight really only counts as one episode of distraction. The key is to repeat at short intervals.
  4. Repeat. Every time you notice your bad habit, give yourself a quick distraction. It will happen

A Note About Recognizing How You’re Feeling In the Moment

This is actually the hardest part because at the end of the day, the mind is a wild landscape and it’s not actually under much control. Your mind mostly does it’s own thing and you actually tune in selectively. Tuning in more often means you’ll have to learn the signals your mind gives you. A big part of this process will be noticing the trigger thoughts, feelings and body sensations that actually tell you your mind is in a dark place.

Lots of what goes on in your mind stays in the dark corners, never really coming to your attention except maybe as a sour feeling in your stomach, tense shoulders, or the sinking feeling that you’ve done something wrong and you’ll never be good enough. All of those things start in your mind even if you don’t hear or listen to the thoughts. It’s especially hard to see if you’re in that state almost constantly. Just keep trying. Even if you notice it twice a day, that’s a huge step forward.

If you really don’t ever notice it, then set alarms for yourself to practice one of the above techniques randomly. Take 2-3 minutes out of your day as often as you can – even hourly while you’re awake. It all adds up and stopping any thought and replacing it with something either entirely neutral, like the stop and drop or joyful, like the fantasy, makes a difference in the tracks your brain will follow.

Share with friends:

Overmethylation – an MTHFR Basic State

Overmethylation, as we have discussed, is the least common state according to the research of Dr. Carl Pfeiffer in his book Nutrition and Mental Illness, An Orthomolecular Approach To Balancing Body Chemistry. Ovmethylation isn’t caused by just one thing – it’s a tendency based on your genes, lifestyle, stressors, diet, and environment. Interestingly – you can be an overmethylator without having an MTHFR mutation at all. Overmethylation also flows on a spectrum, from very mild symptoms to far more severe ones.

If you’re not sure if you’re an undermethylator, methylation neutral, or an overmethylator then visit this post for a comparative chart. As with everything else, even the most severely overmethylated person will have some traits and not others – this is all very individual. The biggest constants are artistic or creative tendencies, empathy and/or social activism, and anxiety.

Overmethylators Are Blessed With Many Positive Traits.

  • Creative
  • Highly artistic or musical
  • Highly empathic and sensitive
  • March to the beat of their own drum
  • Passionate and self-sacrificing
  • High pain threshold

Some of These Traits Have a Darker Side:

  • Obsessive or manic focus on what is important to them (social cause, activism, artistic project)
  • Ruminating – hard to shut brain off
  • Sleep disorders
  • Anxiety
  • A tendency toward self-enhancement (extreme plastic surgery, implants of all types), tattoos, piercings

Overmethylation Can Lead to Physical and Medical Issues

  • Food and chemical sensitivities – this picture is dominated by low histamine which then translates to alternate immune pathway sensitivities.
  • Pain – head, neck, and general body pain.
  • Low Histamine
  • Anxiety or panic
  • Sleep disorders – especially with physical or mental restlessness.
  • Depression – depression – especially with an anxiety component
  • Hyperactivity, ADHD – in combo with restlessness and anxiety

At The Extreme End of Pathology Overmethylators Can Be Prone To:

  • Schizophrenia
  • Panic attacks
  • Self-mutilation or self-harm
  • Major Depression
  • Bipolar Disorder
  • Psychosis including post-partum psychosis

Nutritional Tendencies In Overmethylation

  • Great Reactions to B Vitamins – most overmethylators are low in B vitamins generally, but especially folate and B12 and typically do well with higher than average dosages.
  • Often high copper levels, which can be balanced by increasing zinc
  • Often low histamine
  • Often low B3 and B6
  • Often intolerant to estrogen therapies including birth control and HRT
  • Serotonin, dopamine and norepinephrine may be elevated

Medication and Supplement Reactions in Overmethylation

This represents what is typical for the group, but drug and nutrient reactions can be very personal, so this is a general guideline and not a certainty. This information is both from Dr. Pfeiffer’s book (see above), this article, and my own experience with clients.

Typically Good ReactionTypically Bad Reaction
BenzodiazepinesSSRI Antidepressants
Lithium (Rx) or Lithium OrotateAntihistamines
High-folate foodsEstrogen – birth control pills, hormone replacement therapy
Folate, Folinic Acid, 5-LMTHFSAMe
B12Methionine
B3, B6Copper
ZincTryptophan, phenylalanine
Antioxidants – C, E, A, NAC, etc…St John’s Wort
ManganeseTyrosine
MagnesiumDMG, TMG (methyl donors)
CholineInositol
DMAE
Omega-3 fatty acids

You can read more about overmethylation here.

Share with friends:

Who Should Care About MTHFR Mutation?

On the internets, it seems like everyone cares about MTHFR right now, but honestly, it isn’t necessarily important for everyone. Not even for everyone with a known mutation.

Just having a polymorphism is not a cause for panic. Having an MTHFR mutation, even one that is considered significant will never have any symptoms, signs, or health risks from the polymorphism. Just having the gene doesn’t mean anything at all in terms of supplements you should take, things you should do, or really anything else. In fact, over supplementing can be as harmful to your health as under supplementing.

This girl thinks you should care about MTHFR mutations.

Two Main Factors Make MTHFR Matter

  1. Your circumstances
  2. Your symptoms

Let’s review what MTHFR might do, and then we’ll talk more about circumstances and symptoms.

Possible Health Consequences of the MTHFR mutations

MTHFR mutations have been implicated in at least one research study in:

  • Midline Abnormalities: neural tube defects, anencephaly, spina bifida, cleft palate, cleft lip, and facial asymmetries.
  • Cancer: including breast, lung, brain, stomach, head and neck, and kidney.
  • Cardiac disease: including thrombosis (increased tendency to clot), deep vein thrombosis, high homocysteine levels, pre-eclampsia (high blood pressure in and around pregnancy), vascular dementia.
  • Fertility issues: including miscarriages or multiple pregnancy loss, low sperm count, history of children with birth defects.
  • Neurological issues: including migraines, autism, Alzheimer’s dementia.
  • Mood and Psychological issues: including anxiety, depression, obsessive-compulsive traits or tendencies, bipolar disorder, and schizophrenia. Also, reduced reactions to certain medications like SSRIs for depression, and increased tendency toward addictions.
  • Abnormal Reactions to Medications and Therapies – including methotrexate, FOLFOX (a combination chemotherapeutic agent), SSRI medications for depression, some vitamins including folic acid, methyl-B12, betaine, and others.

When Should You Be Concerned?

This is simple. These are the circumstances that matter:

  • Fertility and Pregnancy – if you suspect you or your partner might have an MTHFR issue and you’re considering having a baby, it matters to know so you can get your health right before you build a baby.
  • Treatments for Depression and Anxiety aren’t Working – this is a strong indicator that there is something underlying the issue that isn’t being addressed, and none of the medications out there manage MTHFR issues.
  • You Have a Strong Family History of Early Cardiac Death – it might not be related to MTHFR, but if it is then knowing your MTHFR status gives you something you can work on, instead of waiting for the ax to fall.
  • You Have Three Known Bad Copies of MTHFR – this is three compromised copies of significant MTHFR SNPs (C677T and A1298C) out of four.

Who Should Care about MTHFR Polymorphisms?

These are the symptoms that matter. If you or your genetically related family members have more than three of the following, then your life might get better by addressing your methylation, whether you know about your MTHFR or not.

  • Anxiety
  • Overachieving tendencies
  • Perfectionism
  • Obsessive thoughts
  • Insomnia
  • Cleft lip or cleft palate
  • Spina bifida
  • Abnormal or unexplained clotting
  • Bad reaction to birth control pills
  • Alcohol intolerance
  • Schizophrenia
  • Bipolar disorder
  • Repeat miscarriages
  • Unexplained low sperm count
  • Alzheimer’s dementia
  • Addictions
  • High homocysteine levels
  • Food or chemical sensitivities
  • Intense competitive drive
  • Serum folic acid tests is abnormally high or abnormally low
  • “New car smell” gives you a headache or other symptoms.
  • Taking B vitamins sometimes makes you feel depressed

Who Should Not Be Worried About MTHFR Polymorphisms?

  1. People who know they have no bad copies.
  2. People who know they have one bad copy but have no related symptoms or family histories.
  3. People who don’t know their genetic profile who also don’t have related symptoms or family histories.

Share with friends: