MTHFR mutation, Other Gene SNPs High Histamine, gene SNPs, and MTHFR Histamine and MTHFR are bound together for so many reasons. One, is because just like MTHFR, histamine has its fingers in so much more than just allergies. Histamine is involved in: Histamine levels in your body depend on two factors.… Share with friends:Amy NeuzilMay 19, 2022