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Normal weight obesity (NWO) is a health condition that often goes unnoticed because it hides behind a normal body weight. People with NWO have a body mass index (BMI) within the normal range but carry excess body fat, especially around the abdomen. This post explores normal-weight obesity and MTHFR gene variants, and how these two are linked.

If you’ve been exploring your genetics, you may already be familiar with the MTHFR gene and its role in methylation. But if you also carry a slow MAOA variant, it adds an entirely different layer—one that directly impacts mood, stress response, and neurotransmitter balance. MTHFR and slow MAOA must be optimized together to avoid making symptoms worse.

People with the MTHFR gene mutation often face challenges related to methylation and metabolic health. One promising area of support involves increasing levels of glucagon-like peptide-1 (GLP-1), a hormone that helps regulate blood sugar, appetite, and insulin secretion. It is possible to naturally boost GLP-1 levels for MTHFR gene mutation support and weight reduction.

PEMT quietly works alongside MTHFR, and when both are affected, the impact on health can be much more significant. MTHFR and PEMT must be managed together to avoid consequences to fertility, liver function, neurotransmitters, and more.