Hormones

When people think about estrogen, they usually think about how much of the hormone their body produces. But the other side of this story is how well your body processes and clears estrogen once it's been used. This process, called estrogen metabolism, is just as important as estrogen production itself. One of the body's most important tools for processing estrogen is methylation, a biochemical process supported by the MTHFR gene. MTHFR and hormones are linked.

MTHFR gene variants and hypothyroidism are often found together and several studies have looked at the link between the two, but the only real conclusion we can draw is that the connection is not simple. A 2022 meta-analysis published by Yang et. al. shows that C677T variants are associated with an increased risk of hypothyroidism, while A1298C variants are associated with a lower risk than the average population.

With MTHFR and slow COMT, you may produce neurotransmitters inefficiently (MTHFR), but also break them down slowly (COMT). This can lead to fluctuating dopamine levels, periods of overstimulation or underperformance, and increased sensitivity to small biochemical changes.

If you've been feeling off lately, struggling with unexplained fatigue, mood swings, or other hormone imbalances, you might be wondering if there’s a deeper cause. One possibility that often goes unnoticed is an MTHFR gene mutation, because MTHFR symptoms in females can present differently than they do in males.

As the leaves change color and the air turns crisp, many of us eagerly welcome the warm, nostalgic flavors of pumpkin spice. However, beneath the cozy ambiance lies a concern regarding synthetic fragrances. These chemical blends, often present in candles, air fresheners, and even food products, can significantly impact our health—especially for individuals with MTHFR gene mutations.

Adrenal fatigue is pervasive in modern society because we are not meant for the type of chronic stress we are all facing. It happens in four stages and the first one is surprises everyone.

Adrenal fatigue is everywhere because modern society is almost perfectly designed to push your adrenals to the limit and then some. But what is adrenal fatigue, really?

Sex hormones influence your energy, sleep, motivation and drive. Estrogen, testosterone, and progesterone are all big factors in how you feel on a daily basis.

Castor oil has, in fact, been used for thousands of years and was considered so valuable it was included in the tombs of ancient Pharos in Egypt as early as 4,000 B.C.

Understanding fatigue means understanding what gives you the feeling of having energy in the first place.

MTHFR (methylenetetrahydrofolate reductase) is a gene that provides instructions for making an enzyme of the same name. The MTHFR enzyme...

The idea that methyl folate could be a better option than folic acid in prenatal vitamins is controversial, because folic acid has been the fertility go-to treatment since it was discovered in the 1930s. The issue is, MTHFR had NOT been discovered in the 1930s, and the research hadn't really dived into the genetic needs of infertile couples yet.

This week, I want to talk about one of my favorite tools for hormone balance, which is seed cycling. This is an all-natural, nutritive...

This week, let’s talk about some of the things that women tend to accept as “normal” but that could be indicators of something more...

This week, let’s talk about the hidden tool in women’s fertility arsenals that goes mostly overlooked. It’s your annual exam. A thorough...

This week, let’s talk about basic health parameters, or measurable issues, that it is best to normalize or improve before trying for a...

Female hormones are nothing if not complicated (as anyone who has ever met a woman can affirm). First - a conversation about the...

Women are cyclic creatures, and understanding your cycle can help you understand your moods, body, and head-space. This monthly rhythm...

Naturally, MTHFR and birth control pills interact. It's not like this is an easy mutation to live with in other senses; why would it leave our contraceptive options untouched? Complaining aside, I could have saved myself years of miserable experiences with the pill if I had known this when I was in University.