If you have an MTHFR variant and trouble sleeping, it can be tempting to assume that the answer to "Does MTHFR cause insomnia?" Is a simple "YES." Sadly, like everything else with MTHFR, it's complicated. MTHFR influences folate and one-carbon metabolism (methylation), which in turn affects homocysteine, methionine, S-adenosylmethionine (SAM), neurotransmitter biology and many methylation reactions throughout the body.Sleep itself also changes methylation patterns.

Sleep problems can be divided into four main categories based on the pattern of sleep disturbance that you experience. These patterns can help you narrow down some of the contributing factors in your sleep trouble.