L-5MTHF is the active form of folate, but ironically, it is far less studied than the synthetic (inactive) form folic acid. Because of that, the safe upper limit of L-5MTHF is not known precisely, but we can draw some conclusions from existing data about the risks of high-dose folic acid.

MTHFR and sleep are intertwined, so here are some of the most important things you can do to get the best sleep moving forward.