You get your bloodwork back and your homocysteine is elevated. If you've ever looked at Instagram ever your first thought is probably "It must be MTHFR!" You might be right, especially if you have an MTHFR C677T variant, which is most closely associated with high homocysteine. But there are many other reasons for homocysteine to be elevated, so don't stop looking once you see MTHFR.

With MTHFR and slow COMT, you may produce neurotransmitters inefficiently (MTHFR), but also break them down slowly (COMT). This can lead to fluctuating dopamine levels, periods of overstimulation or underperformance, and increased sensitivity to small biochemical changes.

Toxins are and have been a part of the human situation forever. Even before the industrial era, toxins came from bacteria, yeast, and fungii in food, minerals and biological products in the water, and compounds in the air. Now that humans have turned into giant trash heap creatures, your detoxification systems are always working to keep you alive, but they can't always keep up.

Methylation is a very small, foundational chemical function in your body. It involves the moving of a methyl group, which is a carbon with three hydrogens that you can picture a lot like a Mickey Mouse head with an extra ear (shudder).

Understanding fatigue means understanding what gives you the feeling of having energy in the first place.

Fatigue, which is a feeling of extreme tiredness, weakness, or exhaustion, is the first symptom of almost every medical problem, including MTHFR. It can be linked to almost every body system, and it is the most general symptom we have. It is also linked to a number of common gene SNPs, including MTHFR, fast MAOA, fast COMT, and more. It is tied to lifestyle factors like diet, nutrition, sleep, and stress. So, actually, in light of all of that, it is surprising any of us don't