Histamine and MTHFR are bound together for so many reasons. Histamine levels are affected by methylation, and histamine breakdown is methylation-dependent. Another big reason is that just like MTHFR, histamine has its fingers in so much more than just allergies.

5000 mcg folic acid is the standard recomendation for anyone struggling with low fertility, but current research evidence shows that 5000 mcg folic acid reduces fertility in people with the MTHFR gene mutation, and possibly in peopel without it as well.

High homocysteine is one of the most medically recognized consequences of having an MTHFR gene mutation, and learning to lower homocysteine with MTHFR can protect your health long-term. Balancing your methylation and boosting your B vitamins, especially B2, folate or 5-LMTHF, and B12, is the usual first step with MTHFR. But for true health, there are some other things that matter as well.