With MTHFR and slow COMT, you may produce neurotransmitters inefficiently (MTHFR), but also break them down slowly (COMT). This can lead to fluctuating dopamine levels, periods of overstimulation or underperformance, and increased sensitivity to small biochemical changes.

In clinical practice, however, patterns often emerge before the research fully catches up. One such pattern I observe is a striking overlap between individuals with MTHFR gene variants and symptoms of ADHD or ADD. To be clear: this is not yet a fully established causal relationship. But there is enough emerging evidence—and strong biochemical plausibility—to warrant a closer look.

If you’ve been exploring your genetics, you may already be familiar with the MTHFR gene and its role in methylation. But if you also carry a slow MAOA variant, it adds an entirely different layer—one that directly impacts mood, stress response, and neurotransmitter balance. MTHFR and slow MAOA must be optimized together to avoid making symptoms worse.

Creativity often feels like a mysterious gift, something that flows naturally in some people but not in others. Recent discussions in genetics suggest that a mutation in the MTHFR gene might play a role in shaping creative abilities.

Highly Sensitive People (HSPs) often experience the world differently than others. This unique trait can manifest in various ways, from heightened emotional responses to an acute awareness of sensory stimuli. Understanding the neurological and genetic underpinnings of HSP can help individuals identify these traits in themselves and navigate their sensitivities more effectively.