Vitamin B6 supports brain function, helps produce neurotransmitters, and assists in red blood cell formation. Because of these benefits, some people take supplements in doses far exceeding the recommended daily allowance (RDA), hoping to improve mood, reduce anxiety, or manage neuropathic pain. The RDA for adults is about 1.3 to 2 mg per day, but some supplements provide doses of 50 mg or more, sometimes reaching several hundred milligrams daily.

High homocysteine is one of the most medically recognized consequences of having an MTHFR gene mutation, and learning to lower homocysteine with MTHFR can protect your health long-term. Balancing your methylation and boosting your B vitamins, especially B2, folate or 5-LMTHF, and B12, is the usual first step with MTHFR. But for true health, there are some other things that matter as well.