If you’ve been exploring your genetics, you may already be familiar with the MTHFR gene and its role in methylation. But if you also carry a slow MAOA variant, it adds an entirely different layer—one that directly impacts mood, stress response, and neurotransmitter balance. MTHFR and slow MAOA must be optimized together to avoid making symptoms worse.

PEMT quietly works alongside MTHFR, and when both are affected, the impact on health can be much more significant. MTHFR and PEMT must be managed together to avoid consequences to fertility, liver function, neurotransmitters, and more.

These two complex symptoms have a terrifyingly circular relationship, often blending seamlessly into each other, making it impossible to tell where one ends and the other begins

Understanding fatigue means understanding what gives you the feeling of having energy in the first place.

We blame neurotransmitters for everything, and try to use them to fix every mental health disorder in the book, but should we? Depression must be low serotonin, and anxiety must be too low or too high norepinephrine. But this view has its limits, and more and more research is confirming that neurological inflammation may be as important or even more important than neurotransmitter levels.