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Supplements to Help You Stay Asleep

Updated: Jun 13

Staying asleep comes down to managing everything that would wake you up, like blood sugar, nighttime cortisol spikes, histamine, hormones, and pain. Supplements to stay asleep have to cover whichever of these problems you're struggling with. Let's talk about those things with the exception of pain, which is its giant topic, and very personal to the circumstance and type of pain.





General Supplements to Help You Stay Asleep


Time-release melatonin - I waxed poetic about melatonin in the last podcast episode/blog post because I love it so much. Melatonin, however, has a short duration of action, and for some people, it puts them to sleep well, but they wake up after a few of hours feeling ready to go. Sadly, ready-to-go is inconvenient if it happens at 2:00 am. For some people, a time-release or extended-release melatonin will solve this problem nicely, giving them a slow and steady dose through the night.


Some people notice that if they take extended-release melatonin, they feel a little groggy the following morning, like perhaps some melatonin is still being released after waking. This is especially true if you take the melatonin around midnight and expect to get up at 6:00 am because the extended release is supposed to last roughly eight hours. Also, remember that human metabolism is nothing if not tricksy, so the actual release duration in your body could be different than the target.


Supplements to Help Manage Blood Sugar Overnight


Nighttime blood sugar spikes and drops can cause anything from micro-arousals to full waking events. In diabetes, something called the "dawn phenomenon" is well documented. In this situation, your early morning rise in blood sugar, somewhere between 3:00 and 7:00 am, is not managed by a rise in insulin. I see this happen in many people who test normal for blood sugars, but who have a lot of ups and downs throughout the day as well.


Addressing this problem long-term comes down to managing your blood sugar overall. If you're all over the map during the day, it's unreasonable to expect your body to keep it steady overnight. But while you're implementing changes like adopting a low glycemic index diet and following Jesse Inchauspe's Glucose Goddess Method hacks, there are a few additional things you can do to help smooth out your nights and get better sleep.


  • Make sure your evening meal is heavily weighted toward protein, good fats like olive oil or grass-fed meat fats, and vegetables. Leave the carbs out.

  • Add a fiber supplement to your last glass of water of the day. This will also help to smooth out blood sugars.

  • Consider a blood sugar management supplement before bed. There are several great formulas, but look for one with proven ingredients like alpha-lipoic acid, chromium, inositol, bitter melon, gymnemna sylvestra, or berberine.

  • Focus on controlling sugars, starches, and carbs in your diet. I suggest a step-down program that starts with extremely limited carbs for a month or so to break the carbohydrate habit, then gradually allows more in a balanced way.

  • If you have been diagnosed with diabetes and are experiencing this symptom, it could be a sign that your prescription medications are inadequate or that your insulin timing needs adjusting. Talk with your doctor about it to see if they can make changes that help you sleep through the night.



Supplements To Manage Cortisol Overnight


Night-time cortisol spikes reflect a larger problem: your adrenals are overtaxed and trying to keep up with too many demands. This is called adrenal fatigue and is very common in North America as we push harder to achieve, earn, keep up with the Joneses, and otherwise fulfill unrealistic cultural expectations. Not that I have an opinion about it or anything. When this fatigue is in its early stages, what we see is the adrenals eagerly pushing out cortisol around 4:00 am, doing their best to stay ahead of the morning rush, which then causes an early wake-up, adds to sleep loss, and makes the problem worse in the long term.


In this situation, supporting your adrenals and their health during the day is a great idea, and we'll dive into that topic in more depth later this season. Overnight, however, I only know about one supplement that helps control nighttime cortisol spikes. It's called Cortisol Manager from Integrated Therapeutics. It takes a few nights to work, and some people say they feel a little less energetic during the day when they take it, which makes sense because it's keeping your body from doing the early adrenaline rush, but overall, it's the only one I've seen help to manage this problem. Remember, it isn't enough by itself, and some daytime support for your adrenals is important here.


Lowering Histamine Overnight


We've talked a bit about high histamine at night. If you wake up because of histamine, it usually feels like you're too hot, your mind is racing, and for some people, your skin gets itchy. Also, it's usually food or drink dependent - some nights it happens and some nights it doesn't, and it's more likely to happen on nights when you have a drink of alcohol or eat something higher in histamine, like leftovers.


If this happens, then supplements can help to take the edge off, but the real fix is making diet changes that will help to bring down your histamine levels long term. To manage this in the moment, try taking activated charcoal before bed, a DAO enzyme which helps to break down the histamine in foods, with your evening meal, and ix-nay on the inks-dray, or, in plain English, stop with the alcohol. In the future, go for fresh, low-histamine foods and avoid fermented, aged, or histamine-rich fare.


Supplements to Help Balance Hormones


Women's hormones are a big topic with sleep disturbance, and women in transitional hormone times, like perimenopause, can vouch for this. In general, estrogen is the hormone that is more likely to keep you awake, and progesterone is the one that helps you fall asleep. The problem is that if you're estrogen-dominant or tend in that direction, then any progesterone you take gets converted to estrogen as quickly as you take it. The best policy, then, is to help your body manage the estrogens with something like ground flax seeds, which help bind to estrogen in the gut and eliminate it it. It also helps to balance the ratios between stronger and weaker estrogens to reduce their detrimental effects. This can also be done with a supplement like Indole-3-carbinol, but flax seeds are much less expensive. Flax seeds can also help if you supplement progesterone to reduce the amount converted to estrogen.


Women's hormones are a massive topic, and if you're interested in this specifically, I would highly recommend going back and listening to Season 3 of the To Health With That! Podcast, which is all about fertility and hormone balance. Also, check out the Webinar on Seed Cycling and the 6-week course about balancing Women's hormones.

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Please Read: The information here is for educational purposes only. Please consult with your primary care physician before making changes to your diet, supplements, or pharmaceutical medications. If you are having a medical emergency, please call 911. Your life and health are precious.

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