THRIVE with MTHFR.

Welcome! I’m Amy. I’m would love to help you optimize your genetic gifts so you can live your healthiest, happiest, most productive life.

If you’ve got MTHFR, you’ve got options:

Genetic Rockstars Is Best For You If:

  • You know or suspect you have an MTHFR mutation and want to be the best and healthiest version of yourself.

  • You are the classic overachiever, always pushing, always working, always striving but having a hard time with balance.

  • You are the black sheep – artistic, passionate, and intense, Struggling to leave your mark on the world without getting eaten up.

  • You are the parent, partner, bestie, or caregiver for someone with the MTHFR mutation and you want to be there for them.
  • You are really into getting an awesome community for less than the price of one fancy coffee per month.

MTHFR Academy is closed to new clients at this time. Email me if you’re interested in joining the next cycle!

  • It’s amy @ tohealthwiththat . com

One-on-one Coaching is The Best Choice For You if:

  • You have MTHFR along with some very specific health needs and want that one-on-one time.
  • You’re not really into the group thing.

Amy is a health coach and host of the To Health With That! Podcast. She helps people like you find their happiest, healthiest, most productive selves in a way that actually works in real life. She’s a naturopathic doctor, has a B.A. in psychology, and has been on her own journey with a compound heterozygous MTHFR mutation.

If you know you want more detail – you can download your 108 page Get Started Guide with workbooks, phases of healing, and more.


  • Nitric Oxide, MTHFR, and NOS3
    MTHFR is well known for causing heart health issues. It’s directly responsible for raising homocysteine levels, it’s implicated in troublesome blood clotting, and it’s indirectly responsible for making it harder to make adequate nitric oxide. All of this is compounded if you have MTHFR and another gene SNP called NOS3. What is Nitric Oxide? Nitric … Continue reading Nitric Oxide, MTHFR, and NOS3
  • S2E33: GST and GPX – Gene SNPs the Affect Glutathione
    Last week we reviewed glutathione and its absolutely crucial importance in the body. We also spoke about it in S1E14: MTHFR and Glutathione that details some of the symptoms and diseases linked to low glutathione status and goes over the basics about how MTHFR affects glutathione. This week, let’s talk about the two most well … Continue reading S2E33: GST and GPX – Gene SNPs the Affect Glutathione
  • S2E32: Glutathione Review with gene SNPs GGS, and GGT.
    We haven’t discussed glutathione in a while, but MTHFR’s effects on glutathione production are of major consequence in the health of all of us MTHFR folks. While a sluggish methylation typically leads to a sluggish glutathione production, there are some particular gene SNPs that have a far greater impact. The most notable are GGS, GGT, … Continue reading S2E32: Glutathione Review with gene SNPs GGS, and GGT.
  • S2E31: COMT Fast
    The COMT fast picture, as you can imagine, is the flip-side of COMT slow. This enzyme works too well, eliminating crucial substances before they have the chance to act. The most well researched polymorphism that contributes to this picture is the COMT Val158Met Val/Val pattern, but again total COMT activity is additive across all the … Continue reading S2E31: COMT Fast
  • S2E30: Slow COMT
    This week, let’s talk about our first of two COMT pictures. COMT slow. Remember, this means the COMT enzyme is less efficient than normal so the catecholamines it is supposed to break down stay in circulation longer. This leads to high neurotransmitters including dopamine, norepinephrine, and epinephrine. It also means high levels of hormones, including … Continue reading S2E30: Slow COMT
  • S2E28: COMT and MTHFR.
    To kick off our series on other polymorphisms, I’m starting with another heavy-hitter that is deeply entwined with MTHFR.  This polymorphism is also in a gene that codes for an enzyme by the name of catechol-O-methyltransferase. I’m hoping that right off the bat, you noticed the word “methy”l in there as part of the enzyme … Continue reading S2E28: COMT and MTHFR.

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8 thoughts on “THRIVE with MTHFR.”

  1. Hi Dr.Amy!

    I’m so grateful I came across your podcast. I’ve only listened to about 8 so far… you’re right, it’s a lot of information in a little bit! I have so many questions but for know I will just ask two…
    1) Typically how long before you may notice results from taking b vitamins? (Like the B minus from Seeking Health)
    2) Is it safe to take daily SAMe or should you pulse it?
    Looking forward to hearing back!

    1. Hi Holly,
      I’m so glad you’ve been enjoying the podcast – that is great news!
      In terms of “results” – it depends on what you’re looking for. Usually, people notice mood or energy level changes first, and those are very dose-dependent. I try to encourage people to give a dose at least 2 weeks (and more if you’re very sensitive) to see how your body responds before you think of increasing or changing. If you’ve been taking the B minus with no negative effects for 2 weeks and you aren’t seeing too much of a change, you could think about adding in a separate 5-LMTHF at a very low dose and seeing how you respond (or if you know you don’t tolerate 5-LMTHF, then maybe an additional folinic acid or a workaround like the SAMe.)

      SAMe is safe to take daily and works best on an empty stomach (30 minutes before a meal or 2 hours after).
      I hope this is helpful and I hope you’ll consider joining the Genetic Rockstars community – click the link to find out more.

  2. Hi, I’m trying to get ahold of the practice but don’t know how. My patient portal link is no longer valid because I was told I was putting the wrong birthday in when I was registering but I was now. Can you please point me on the right direction and provide contact info to whom I need to talk to to help me

  3. I am so glad that I came across your podcasts and blog posts! I have fallen down the rabbit hole of many of your blog posts… but is there a place you have all of them stored so I can read them in order? So grateful for your scientific approach, well-documented statements, and overall thoroughness for the MTHFR topic!

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