MTHFR lifestyle, MTHFR mutation MTHFR and Pain Medications – NSAIDS, Opiates, and Alternatives. This whole week’s topic stemmed from a call-in question from Jane Turner that piqued my curiosity, so thanks, Jane! Here’s the question: I just found out that I’m an MTHFR mutant… I have some pain issues, and I was wondering… Share with friends:Amy NeuzilJanuary 10, 20218 Comments